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TPS3148 : Trial in progress abstract phase I trial of 5-aza-4-thio-2-deoxycytidine (Aza-TdC) in patients with advanced solid tumors.

Researchers

Presenter

  • M. Cecilia Monge B

Principal Investigators

  • Geraldine Helen O'Sullivan Coyne

  • Richard Piekarz

  • Naoko Takebe

  • Ashley Bruns

  • Arjun Mittra

  • Sabrina Sharmin Khan

  • Jerry M. Collins

  • Larry Anderson

  • Lamin Juwara

  • Brandon Miller

  • Robert J. Kinders

  • Larry Rubinstein

  • Alice P. Chen

Medical Centers

  • National Human Genome Research Institute, National Institutes of Health, Bethesda, MD

  • Developmental Therapeutics Clinic/Early Clinical Trials Development Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD

  • Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD

  • Developmental Therapeutics Clinic/Early Clinical Trials Development Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD

  • National Cancer Institute, Bethesda, MD

  • Division of Cancer Treatment and Diagnosis, Natl Cancer Inst, Bethesda, MD

  • National Cancer Institute/Division of Cancer Treatment and Diagnosis, Rockville, MD

  • National Cancer Institute/Division of Cancer Treatment and Diagnosis/Developmental Therapeutics Program/Office of the Associate Director, Frederick National Laboratory for Cancer Research, Frederick, MD

  • NCI at Frederick, Bethesda, MD

  • Frederick National Laboratory of Cancer Research, Frederick, MD

  • 1050 Boyles Street, Frederick, MD

  • Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD

  • Center of Cancer Research, Bethesda, MD

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • N/A

Biomarkers

  • Circulating tumor cells

Drug/Treatment

  • Decitabine

  • thiocoraline

Outcome

  • N/A

Study Design

  • Pharmacodynamics

  • Dose Escalation

  • Cohort

Phase

  • I

Study Id's

  • NCT03366116

Sponsors

  • N/A

Result

  • N/A

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