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TPS4158 : NET-02: A multi-center, randomised, phase II trial of liposomal irinotecan (nal-IRI) and 5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line therapy in patients (pts) with progressive poorly differentiated extra-pulmonary neuroendocrine carcinoma (PD-EP-NEC).

Researchers

Presenter

  • Mairead Geraldine McNamara

Principal Investigators

  • Jayne Swain

  • Zoe Craig

  • Jonathan Wadsley

  • Nicholas Reed

  • Olusola Olusesan Faluyi

  • Angela Lamarca

  • Richard Hubner

  • Wasat Mansoor

  • Debashis Sarker

  • Helen C Howard

  • David A. Cairns

  • Tim Meyer

  • Juan W. Valle

Medical Centers

  • Institute of Cancer Sciences, University of Manchester, Medical Oncology Department, The Christie NHS Foundation Trust, Manchester, United Kingdom

  • University of Leeds, Leeds, United Kingdom

  • Weston Park Hospital, Sheffield, United Kingdom

  • Beatson Oncology Centre, Glasgow, United Kingdom

  • Clatterbridge Cancer Centre, Merseyside, United Kingdom

  • Department of Medical Oncology, The Christie NHS Foundation Trust / Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom

  • The Christie NHS Foundation TRUST, Manchester, United Kingdom

  • NHS, Manchester, United Kingdom

  • King's College Hospital, Institute of Liver Studies, London, United Kingdom

  • Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom

  • Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom

  • University College London Hospitals/UCL Cancer Institute, London, United Kingdom

  • Institute of Cancer Studies, University of Manchester, The Christie Hospital, Manchester, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • N/A

Biomarkers

  • Circulating tumor cells

  • Circulating DNA

Drug/Treatment

  • Irinotecan

  • Adrucil injection

  • Fluorouracil

  • L-leucovorin

  • Docetaxel

Outcome

  • N/A

Study Design

  • Randomized

  • Multicenteric

Phase

  • II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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