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2296 : Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Inhibit Platelet Aggregation In Vitro and Protect Mice From Arterial and Venous Thrombosis In Vivo

Researchers

Presenter

  • Gilbert Acevedo

Principal Investigators

  • Brian R. Branchford

  • Christine Brzezinski

  • Douglas K. Graham

  • Jorge A. DiPaola

  • Susan Sather

  • Gary Brodsky

  • Deborah DeRyckere

  • Weihe Zhang

  • Jing Liu

  • H. Shelton Earp III

  • Xiaodong Wang

  • Stephen V. Frye

Medical Centers

  • Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC

  • Dept of Pediatrics, Univ of Colorado, Sch of Medicine, Aurora, CO

  • Department of Pediatrics, University of Colorado/Childrens Hospital Colorado, Aurora, CO

  • Dept Pediatrics, University of Colorado Hemophilia and Thrombosis Center and Children's Hospital Colorado, Aurora, CO

  • Dept of Pediatrics - Pediatric Heart Lung Center, University of Colorado School of Medicine, Aurora, CO

  • Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, NC

  • Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Denver, Aurora, CO

  • Lineberger Comprehensive Cancer Center at the University of North Carolina, Chapel Hill, NC

  • University of Colorado Denver School of Medicine, Aurora, CO

  • Pediatrics - Hematology/Oncology/BMT, University of Colorado, Aurora, CO

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

  • Blood/haematological Diseases

  • Pulmonary/Respiratory Diseases

Disease

  • Venous thrombosis

Biomarkers

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Drug/Treatment

  • Phosphatidylinositol

  • Epinephrine

  • Adrenaclick

  • L-Tyrosine

  • DMSO

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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