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2215 : Heme Potently Stimulates Tissue Factor Expression By Peripheral Blood Monocytes: A Novel Mechanism For Thrombosis In Intravascular Hemolytic Diseases

Researchers

Presenter

  • Teena Rehani

Principal Investigators

  • Kristin Mathson

  • John D. Belcher

  • Gregory M Vercellotti

  • Arne Slungaard

Medical Centers

  • Division of Hematology Oncology and Transplantation, University of Minnesota, Minneapolis, MN

  • Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

  • Division of Hematology Oncology and Transplantation, University of Minnesota, Minneapolis, MN

  • University of Minnesota, Minneapolis, MN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Infectious Diseases (ID)

Disease

  • Sickle cell anemia

  • Venous thrombosis

  • Porphyria

  • Anemia

  • Sepsis

Biomarkers

  • Nicotinamide adenine dinucleotide phosphate oxidase

  • Peripheral blood mononuclear cell

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Glial cell-derived neurotrophic factor

  • Coagulation Factor III, Tissue Factor

  • Extracellular signal-regulated kinase

  • Toll like receptor 4

Drug/Treatment

  • andrographolide

  • Polymyxin B

  • U-0126

  • hemin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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