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167 : The T Cell Receptor As An Oncogene: Thymic Expression Of Self-Reactive T Cell Receptors Targeting Survivin Induces T-Cell Lymphoblastic Leukmia

Researchers

Presenter

  • Yongzhi Cui

Principal Investigators

  • Masahiro Onozawa

  • Leigh Samsel

  • Haven Garber

  • Hua Zhang

  • Haiying Qin

  • Terry J Fry

  • J. Philip McCoy

  • Xiaolin Wu

  • Peter D Aplan

  • Crystal L Mackall

Medical Centers

  • Flow Cytometry Core Facility, National Heart, Lung and Blood Institute, Bethesda, MD

  • Radiation Oncology Branch, National Cancer Institute at the National Institutes of Health, Bethesda, MD

  • Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

  • Radiation Oncology Branch, National Cancer Institute at the National Institutes of Health, Bethesda, MD

Locations

  • United States

Companies

  • SAIC-Frederick, Inc.

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • T-cell acute lymphoblastic leukemia

Biomarkers

  • Neurogenic locus notch homolog protein 1

  • Cluster of Differentiation 2

  • Cluster of Differentiation 2AP

  • Cluster of Differentiation 4

  • Cluster of differentiation 8A

  • Glycoprotein 100

  • WT1 Transcription Factor

  • T-cell receptor

Drug/Treatment

  • GP100

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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