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112 : Genetic and Pharmacologic Targeting Of Alox5 Attenuates JAK2V617F Induced PV In Mice

Researchers

Presenter

  • Yaoyu Chen

Principal Investigators

  • Yi Shan

  • Zhiru Guo

  • Aibin Liang

  • Shaoguang Li

Medical Centers

  • Department of Urology, Changhai Hospital, Shanghai, China

  • Division of Hematology Oncology, Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA

Locations

  • United States

  • China

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Myeloid neoplasms

  • Chronic Myelogenous Leukemia

  • Essential thrombocythemia

  • Hematological malignancies

  • Acute Leukemia

  • Venous thrombosis

Biomarkers

  • Mitogen-activated protein kinase

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Cytoglobin

  • Hematocrit

Drug/Treatment

  • L-Tyrosine

  • zileuton

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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