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59 : High Intra-Individual Variability In Systemic Exposure To 6 Mercaptopurine (6MP) In Children With Acute Lymphoblastic Leukemia (ALL) Contributes To ALL Relapse: Results From a Childrens Oncology Group (COG) Study (AALL03N1)

Researchers

Presenter

  • Smita Bhatia

Principal Investigators

  • Lindsey Hageman

  • Glen Lew

  • Kelly Maloney

  • Leo Mascarenhas

  • Jane Meza

  • A. Kim Ritchey

  • Amanda Termuhlen

  • William L. Carroll

  • F. Lennie Wong

  • Mary V. Relling

  • Can-Lan Sun

  • Heeyoung Kim

  • Nancy Kornegay

  • William E. Evans

  • Bruce C. Bostrom

  • Jacqueline Casillas

  • M.S.H.S

  • Anne Angiolillo

Medical Centers

  • Dept. of Pediatrics, Div. of Hem./Onc., Univ. of California, Los Angeles, Los Angeles, CA

  • Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN

  • Department of Population Sciences, City of Hope, Duarte, CA

  • Nephrology, Childrens Hospital of Pittsburgh, Pittsburgh, PA

  • Children's Hospital Colorado, Aurora, CO

  • Information Sciences, City of Hope National Medical Center, Duarte, CA

  • Emory University, Aflac Cancer and Blood Disorders Center, Childrens Healthcare of Atlanta, Atlanta, GA

  • Cancer Institute, New York University, New York, NY

  • Jonathan Jaques Childre-s Cancer Center, Miller Childre-s Hospital, Long Beach, CA

  • Pediatrics, USC Keck School of Medicine at CHLA, Los Angeles, CA

  • Preventive and Societal Medicine, Nebraska Medical Center, Omaha, NE

  • Children's Hospitals and Clinics of Minnesota, Minneapolis, MN

  • Children's Natl Medcl Ctr, Washington, DC

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Thiopurine S-methyltransferase

  • Thyroglobulin

Drug/Treatment

  • Allmercap

  • Tabloid

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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