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1087 : ADAM28 Metalloprotease Domain Is Sufficient For Proteolytic Cleavage Of Von Willlebrand Factor

Researchers

Presenter

  • Hayley A. Hanby

Principal Investigators

  • Xiao-hui Zhang

  • X. Long Zheng

Medical Centers

  • Department of Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA

  • Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

  • Peking University Peoples Hospital & Peking University Institute of Hematology, Beijing, China

Locations

  • United States

  • China

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

  • Blood/haematological Diseases

  • Pulmonary/Respiratory Diseases

Disease

  • Thrombotic thrombocytopenic purpura

  • Non Small Cell Lung cancer

  • Small cell lung cancer

  • Breast cancer

  • Lung Cancer

  • Venous thrombosis

Biomarkers

  • Nucleoside diphosphate kinase A

  • C-C Motif Chemokine Ligand 22

  • Immunoglobulin G

  • Insulin Like Growth Factor Binding Protein 3

  • von Willebrand factor

Drug/Treatment

  • thrombospondin-1

  • guanidine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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