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4087 : RAS Pathway Mutations As Predictive Biomarker for Treatment Adaptation in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Isabel S. Jerchel

Principal Investigators

  • Alex Q. Hoogkamer

  • Ingrid M. Aries

  • Gabriele Escherich

  • Ronald W. Stam

  • C. Michel Zwaan

  • Edwin Cuppen

  • Marco J. Koudijs

  • Rob Pieters

  • Monique L. Den Boer

  • Elisabeth M.P. Steeghs

  • Judith M. Boer

  • Nicolle J.M. Besselink

  • Aurelie Boeree

  • Cesca van de Ven

  • Hester A. de Groot-Kruseman

  • Valerie de Haas

  • Martin A. Horstmann

Medical Centers

  • University Medical Center Hamburg Eppendorf, German Cooperative Study Group for Childhood Acute Lymphoblastic Leukemia (COALL), Hamburg, Germany

  • Dutch Childhood Oncology Group, The Hague, Netherlands.

  • Center for Personalized Cancer Treatment, University Medical Center Utrecht, Utrecht, Netherlands

  • Princess Maxima Center for Pediatric Oncology, Netherlands

  • Center for Molecular Medicine, Cancer Genomics Netherlands, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, Netherlands

  • Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands

Locations

  • Germany

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • N/A

Drug/Treatment

  • Trametinib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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