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4083 : Integrated Genomic Analysis of Down Syndrome Acute Lymphoblastic Leukemia Reveals Recurrent Cancer Gene Alterations and Evidence of Frequent Subclonal Driver Events

Researchers

Presenter

  • Oliver A

Principal Investigators

  • Nipun Kakkar

  • Nyla A. Heerema

  • Kelly Maloney

  • Naomi Winick

  • William L. Carroll

  • Elizabeth Raetz

  • Mignon L. Loh

  • Stephen P. Hunger

  • Juhi Jain

  • Harsha Doddapaneni

  • Donna M. Muzny

  • Jacob J. Junco

  • David A. Wheeler

  • Kevin E. Fisher

  • Dolores H. Lopez-Terrada

  • Angshumoy Roy

  • Donald Williams Parsons

  • Karen R. Rabin

  • Jacquelyn Reuther

  • Anne Angiolillo

  • Reuven J Schore

  • Michael J. Burke

  • Wanda Salzer

  • Meenakshi Devidas

  • Andrew J. Carroll

Medical Centers

  • Pathology & Immunology, Baylor College of Medicine, Houston, TX

  • Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY

  • Magnusun Clinical Center, Sliver Spring, MD

  • Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Children's Natl Medcl Ctr, Washington, DC

  • Human Genome Sequencing Cntr, Baylor College of Medicine, Houston, TX

  • Cardiology, Texas Childrens Hospital, Houston, TX

  • Texas Childrens Hospital, Houston, TX

  • Pediatric Center for Personal Cancer Genomics and Therapeutics, Texas Children's Hospital, Houston, TX

  • Hunstman Cancer Institute of Utah, Salt Lake City, UT

  • Division of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI

  • Dept of Biostatistics, Colleges of Medicine, Public Health & Health Professions, University of Florida, Gainsville, FL

  • Department of Pediatrics and the Center for Childhood Cancer Research, Childrens Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

  • Pediatrics (Hem/Onc and ID) and Microbiology, University of Texas Southwestern Medical Center, Dallas, TX

  • Department of Pediatrics, Hematology-Oncology, Benioff Childrens Hospital, and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA

  • Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL

  • Department of Pathology and Immunology, Texas Children's Hospital/Baylor College of Medicine, Houston, TX

  • Children's Hospital Colorado, Aurora, CO

  • Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Down syndrome

  • Solid malignancies

Biomarkers

  • N/A

Drug/Treatment

  • Methadone hydrochloride

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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