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4071 : A Novel Multiplex NGS-Based Digital MLPA Assay for Copy Number Detection of 700 Target Sequences in Childhood Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Ilse Zondervan

Principal Investigators

  • Jan Schouten

  • Karel de Groot

  • Farzaneh Ghazavi

  • Virinder Sarhadi

  • Pieter Van Vlierberghe

  • Barbara De Moerloose

  • Christine Harrison

  • Claire Schwab

  • Sakari Knuutila

  • Tim Lammens

Medical Centers

  • Northern Institute for Cancer Research Newcastle University, Newcastle, United Kingdom

  • Centre for Medical Genetics, Ghent University Hospital, Ghent, Belgium

  • R&D Department, MRC Holland, Amsterdam, Netherlands

  • Leukaemia Research Cytogenetics Group, Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, United Kingdom

  • Faculty of Medicine, Department of Pathology, University of Helsinki, Helsinki, Finland

  • Cancer Research Institute Ghent (CRIG), Ghent, Belgium

  • Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium

  • Centre for Medical Genetics, Ghent University Hospital, Ghent, Belgium

  • Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium

Locations

  • Finland

  • United Kingdom

  • Belgium

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • T-cell acute lymphoblastic leukemia

Biomarkers

  • MYB proto-oncogene, transcription factor

  • Neurogenic locus notch homolog protein 1

  • Breakpoint Cluster Region

  • Paired box 5

  • Phosphatase and tensin homolog

  • Protein AF-9

  • CREB-binding protein

  • Cyclin Dependent Kinase Inhibitor 2A

  • Retinoblastoma protein

  • Enhancer of zeste homolog 2

  • ETS transcription factor ERG

  • ETV6-RUNX1

  • Fragile histidine triad

  • LIM Domain Only 1

  • Transducin Beta Like 1 X-Linked Receptor 1

  • Tumor protein p53

  • Neurofibromatosis type 1

Drug/Treatment

  • TP53

  • EZH2

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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