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4068 : Mutational Landscape, Clonal Evolution Patterns and Role of RAS Mutations in Relapsed Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Koichi Oshima

Principal Investigators

  • Ana Carolina da Silva Almeida

  • Concepci

  • n Nicolas

  • Milagros Balbin

  • Maria Luisa Sulis

  • Motohiro Kato

  • Katsuyoshi Koh

  • Maddalena Paganin

  • Giuseppe Basso

  • Julie M. Gastier-Foster

  • Meenakshi Devidas

  • Gannie Tzoneva

  • Mignon L. Loh

  • Renate Kirschner-Schwabe

  • Teresa Palomero

  • Raul Rabadan

  • Adolfo A. Ferrando

  • Francesco Abate

  • Alberto Ambesi-Impiombato

  • Marta Sanchez-Martin

  • Zachary Carpenter

  • Alexander Penson

  • Arianne Perez-Garcia

  • Cornelia Eckert

Medical Centers

  • Dept. of Pediatrics and the Hellen Diller Family Comprehensive Cancer Center, Benioff Children's Hospital, University of California at San Francisco, San Francisco, CA

  • Department of Pathology, Columbia University, New York, NY

  • Hospital Universitario Central de Asturias, Oviedo, Spain

  • Dept of Biostatistics, Colleges of Medicine, Public Health & Health Professions, University of Florida, Gainsville, FL

  • Institute for Cancer Genetics, Columbia University, New York, NY

  • University of Pavia, Pavia, Italy

  • Institute for Cancer Genetics, Columbia University, New York, NY

  • Department of Pediatrics, University of Bari, Bari, Italy

  • Department of Pediatrics, Columbia University, New York

  • Columbia University Medical Center, New York, NY

  • Department of Hematology/Oncology, Saitama Childrens Medical Center, Saitama, Japan

  • Department of Pathology and Laboratory Medicine,, Nationwide Children's Hospital, Columbus, OH

  • Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Department of Pediatrics, Columbia University Medical Center, New York, NY

  • Department of Systems Biology and Department of Biomedical Informatics, Columbia University Medical Center, New York, NY

  • Rheumatology Department. Hospital Universitario Central de Asturias, Oviedo, Spain

  • Department of Biomedical Informatics, Columbia University Genomic Center, New York, NY

  • Department of Pathology, Columbia University, New York, NY

  • Department of Hematology/Oncology, Saitama Childrens Medical Center, Saitama, Japan

  • Department of Pediatric Oncology/Hematology, Charite Medical University Berlin, Berlin, Germany.

  • Department of Pathology, Columbia University, New York, NY

Locations

  • Japan

  • Italy

  • Spain

  • Germany

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Protein Tyrosine Phosphatase, Non-Receptor Type 11

  • GTPase Nras

  • KRAS proto-oncogene, GTPase

Drug/Treatment

  • Methotrexate

  • Vincristine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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