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4048 : CD47 Blockade Enhances Therapeutic Activity of TCR Mimic Antibodies to Ultra-Low Density Cancer Epitopes through Cytokine Feed Forward Mechanisms

Researchers

Presenter

  • Melissa D Mathias

Principal Investigators

  • Jonathan T Sockolosky

  • Aaron Yu-Yuan Chang

  • Cheng Liu

  • K. Christopher Garcia

  • David A. Scheinberg

Medical Centers

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Eureka Therapeutics Inc, Emeryville, CA

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Solid malignancies

Biomarkers

  • Cluster of Differentiation 47

  • Cytokine

  • Tumor necrosis factor

  • T-cell receptor

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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