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2812 : Biomarker Profiling Differentiates Sepsis from Cytokine Release Syndrome in Chimeric Antigen Receptor T-Cell Therapy for Acute Lymphoblastic Leukemia (ALL)

Researchers

Presenter

  • Simon F. Lacey

Principal Investigators

  • Pamela A Shaw

  • David T Teachey

  • Carl H June

  • Jan J. Melenhorst

  • Scott L. Weiss

  • Fang Chen

  • Vanessa E Gonzalez

  • Noelle Frey

  • David L Porter

  • Shannon L Maude

  • Stephan A Grupp

  • Edward Pequignot

Medical Centers

  • Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

  • Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA

  • Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA

  • Center for Childhood Cancer Research, Childrens Hospital of Philadelphia, Philadelphia, PA

  • Childrens Hospital of Philadelphia, Philadelphia, PA

  • Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

  • Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Infectious Diseases (ID)

Disease

  • Acute lymphoblastic leukemia

  • Cytokine release syndrome

  • Sepsis

Biomarkers

  • Angiopoietin 2

  • Pentraxin-3

  • Plasminogen activator ihnibitor-1

  • Cytokine

  • Intercellular adhesion molecule 1

Drug/Treatment

  • ICAM-1

  • CTL019

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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