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1635 : PI3K and MEK Inhibition in Hypodiploid Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Evan Comeaux

Principal Investigators

  • Wenwei Lin

  • Taosheng Chen

  • Burgess Freeman III

  • Charles G. Mullighan

Medical Centers

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • St. Jude Children's Research Hospital, Memphis, TN

  • Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Chemical Biology and Therapeutics, St. Jude Childrens Research Hospital, Memphis, TN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Cyclin-dependent kinase 4

  • Serine/threonine-protein kinase mTOR

  • Tumor protein p53

  • Neurofibromatosis type 1

Drug/Treatment

  • TP53

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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