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886 : A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias

Researchers

Presenter

  • Alice Giustacchini

Principal Investigators

  • Silvia Nucera

  • Eric R. Lechman

  • Luigi Naldini

  • Bernhard Gentner

  • Cristiana Fanciullo

  • Francesco E Boccalatte

  • Tiziana Plati

  • Anna Ranghetti

  • Luca Vago

  • Massimo Bernardi

  • Maurilio Ponzoni

  • John E. Dick

Medical Centers

  • Hematology and Bone Marrow Transplantation Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milano, Italy

  • Gene Transfer Technologies, San Raffaele Institute, Milan, Italy

  • Department of Cellular & Molecular Biology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada

  • Princess Margaret Cancer Centre University Health Network, Toronto, Ontario, Canada

  • Department of Medical Oncology, San Raffaele Scientific Institute, Milan, Italy

  • San Raffaele Scientific Institute, Milan, Italy

Locations

  • Canada

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Diffuse large B-cell lymphoma

  • Acute lymphoblastic leukemia

  • Hematological malignancies

  • Acute myelocytic leukemia

  • B cell lymphomas

  • Acute Leukemia

  • Lymphomas

Biomarkers

  • p53

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Cluster of Differentiation 19

  • Cluster of Differentiation 34

  • Cluster of Differentiation 38

  • Cluster of differentiation 45

  • Epidermal growth factor-like domain 7

  • MicroRNA 126

  • PI3K/AKT

Drug/Treatment

  • Tetracycline

  • Doxycycline

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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