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826 : Development and Validation Of a Highly Sensitive and Specific Gene Expression Classifier To Prospectively Screen and Identify B-Precursor Acute Lymphoblastic Leukemia (ALL) Patients With a Philadelphia Chromosome-Like (Ph-like or BCR-ABL1-Like) Signature For Therapeutic Targeting and Clinical Intervention

Researchers

Presenter

  • Richard C. Harvey

Principal Investigators

  • Kathryn G. Roberts

  • Elizabeth A. Raetz

  • Naomi J. Winick

  • William L. Carroll

  • Eileen Stonerock

  • Nyla A. Heerema

  • Andrew J. Carroll

  • Shann-Ching Chen

  • Guangchun Song

  • Jared Becksfort

  • Michael Rusch

  • I-Ming L. Chen

  • Yongjin Li

  • Jing Ma

  • Denise Ell

  • Shalini Reshmi

  • Mignon L. Loh

  • Meenakshi Davidas

  • Stephen P. Hunger

  • Charles G. Mullighan

  • Cheryl L. Willman

  • Susan R. Atlas

  • Edward J. Bedrick

  • Julie Gastier-Foster

  • Jinghui Zhang

  • Daniela S. Gerhard

  • Malcolm A. Smith

  • Eric C. Larsen

Medical Centers

  • Physics and Astronomy, University of New Mexico, Albuquerque, NM

  • Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO

  • University of Florida College of Medicine and Children's Oncology Group, Gainesville, FL

  • St. Jude Children's Research Hospital, Memphis, TN

  • Office of Cancer Survivorship, National Cancer Institute, Bethesda, MD

  • St. Jude Children's Research Hospital, Memphis, TN

  • Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL

  • Internal Medicine, University of New Mexico, Albuquerque, NM

  • Nationwide Children's Hospital, Columbus, OH

  • Neonatology, Benioff Childrens Hospital, University of California San Francisco, San Francisco, CA

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Cancer Center/Pathology, University of New Mexico, Albuquerque, NM

  • Cancer Center/Pathology, University of New Mexico, Albuquerque, NM

  • Maine Childrens Cancer Program, Scarborough, ME

  • Computational Biology, St Jude Children's Research Hospital, Memphis, TN

  • Cancer Institute, New York University, New York, NY

  • New York University Medical Center, New York City, NY

  • Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX

  • Department of Pathology, The Ohio State University, Columbus, OH

  • Nationwide Children's Hospital, Columbus, OH

  • University of New Mexico Cancer Center, Albuquerque, NM

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Peripheral Nervous System

  • Congenital disorder

Disease

  • Acute lymphoblastic leukemia

  • B-cell acute lymphoblastic leukemia

  • Neuropathy, congenital hypomyelinating, 2

Biomarkers

  • AKT Serine/Threonine Kinase 2

  • Mucin 4, Cell Surface Associated

  • Chimerin 2

  • Platelet Derived Growth Factor Receptor Beta

  • Colony stimulating factor 1 receptor

  • Interferon-induced transmembrane protein 1

Drug/Treatment

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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