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825 : Integrated Genomic and Mutational Profiling Of Adolescent and Young Adult ALL Identifies a High Frequency Of BCR-ABL1-Like ALL with Very Poor Outcome

Researchers

Presenter

  • Kathryn G. Roberts

Principal Investigators

  • Deqing Pei

  • Shann-Ching Chen

  • I-Ming L. Chen

  • Meenakshi Devidas

  • Eric C. Larsen

  • William L. Carroll

  • Naomi J. Winick

  • Nyla A. Heerema

  • Andrew J. Carroll

  • Julie Gastier-Foster

  • Elizabeth A. Raetz

  • Jared Becksfort

  • Ching-Hon Pui

  • Sima Jeha

  • James R Downing

  • Elisabeth M. Paietta

  • Steven M. Kornblau

  • Guido Marcucci

  • Wendy Stock

  • Clara D. Bloomfield

  • Daniela S. Gerhard

  • Mignon L. Loh

  • Richard C. Harvey

  • Stephen P. Hunger

  • Cheryl L. Willman

  • Charles G. Mullighan

  • Yongjin Li

  • Guangchun Song

  • Jinjun Cheng

  • Jing Ma

  • Jinghui Zhang

  • Cheng Cheng

Medical Centers

  • University of Colorado School of Medicine/Childrens Hospital Colorado, Aurora, CO

  • Cancer Center/Pathology, University of New Mexico, Albuquerque, NM

  • Office of Cancer Survivorship, National Cancer Institute, Bethesda, MD

  • The James Comprehensive Cancer Center, Ohio State University, Columbus, OH

  • St. Jude Children's Research Hospital, Memphis, TN

  • Pediatric Hematology/Oncology, NYU Cancer Institute, New York, NY

  • Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Health Studies, The University of Chicago, Chicago, IL

  • Department of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX

  • Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX

  • Neonatology, Benioff Childrens Hospital, University of California San Francisco, San Francisco, CA

  • St. Jude Children's Research Hospital, Memphis, TN

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Maine Childrens Cancer Program, Scarborough, ME

  • Computational Biology, St Jude Children's Research Hospital, Memphis, TN

  • St. Jude Children's Research Hospital, Memphis, TN

  • Dept of Biostatistics, Colleges of Medicine, Public Health & Health Professions, University of Florida, Gainsville, FL

  • St. Jude Children's Research Hospital, Memphis, TN

  • Department of Pathology, The Ohio State University, Columbus, OH

  • Cancer Institute, New York University, New York, NY

  • Nationwide Children's Hospital, Columbus, OH

  • University of New Mexico Cancer Center, Albuquerque, NM

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Montefiore Medical Center, Bronx, NY

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Solid malignancies

Biomarkers

  • Abelson murine leukemia viral oncogene homolog 2

  • Breakpoint Cluster Region

  • Paired box 5

  • Platelet Derived Growth Factor Receptor Beta

  • Colony stimulating factor 1 receptor

  • CREB-binding protein

  • ETS transcription factor ERG

  • ETV6-RUNX1

  • Fms related tyrosine kinase 3

  • GTPase Nras

  • Histone-lysine N-methyltransferase 2A

  • KRAS proto-oncogene, GTPase

  • Tumor protein p53

Drug/Treatment

  • L-Tyrosine

  • TP53

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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