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3984 : Cardiac Failure In Juvenile Rats Caused By Continuous Long-Term Exposure To The Tyrosine Kinase Inhibitor Dasatinib Can Be Circumvented By An Intermittent Application Schedule

Researchers

Presenter

  • Paula Geidel

Principal Investigators

  • Josephine Tabea Tauer

  • Nadine Steinbronn

  • Roland Jung

  • Ivo Leuschner

  • Ruth H. Strasser

  • Meinolf Suttorp

Medical Centers

  • University Hospital Carl Gustav Carus, Dresden, Germany

  • Dpt. of Internal Med. & Cardiology, Heart Centre, University Hospital, Dresden, Germany

  • Department of Molecular and Experimental Cardiology, Heart Centre Dresden, Dresden, Germany

  • Experimental Centre, Medical Faculty Univ of Dresden, Dresden, Germany

  • Pediatrics, Univ. Hospital, TU Dresden, Dresden, Germany

  • Pediatric Hematology/Oncology, University Hospital Gustav Carus, Dresden, Germany

  • Inst. of Pathology, Div. of Paidopathology,, Univ. of Schleswig-Holstein, Campus Kiel, Kiel, Germany

Locations

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • Chronic Myelogenous Leukemia

  • Dilated cardiomyopathy

  • Myocardial infarction

  • Cardiotoxicity

  • Congestive heart failure

  • Heart muscle disease

  • Hypertension

Biomarkers

  • Breakpoint Cluster Region

  • Interleukin 6

  • Troponin I

Drug/Treatment

  • dasatinib

  • Imatinib

  • IkT001

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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