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3903 : Frontline-Treatment Of Acute Lymphoblastic Leukemia (ALL) In Older Adolescents and Young Adults (AYA) Using a Pediatric Regimen Is Feasible: Toxicity Results of the Prospective US Intergroup Trial C10403 (Alliance)

Researchers

Presenter

  • Anjali S. Advani

Principal Investigators

  • Selina M. Luger

  • Kristin Coffan

  • William L. Carroll

  • Naomi J. Winick

  • Steven E. Coutre

  • Martin S Tallman

  • Frederick R. Appelbaum

  • Harry P. Erba

  • Richard M. Stone

  • Stephen P. Hunger

  • Richard A. Larson

  • Meenakshi Devidas

  • Wendy Stock

  • Eric C. Larsen

  • Michaela Liedtke

  • Peter M Voorhees

  • Matthew C. Foster

  • David F. Claxton

  • Susan Geyer

  • Edy Parker

Medical Centers

  • Stanford University Cancer Institute, Stanford, CA

  • Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

  • Lineberger Comprehensive Cancer Center at the University of North Carolina, Chapel Hill, NC

  • University of Alabama at Birmingham, Birmingham, AL

  • Cancer Institute, New York University, New York, NY

  • Department of Epidemiology & Health Policy Research, Children's Oncology Group & University of Florida College of Medicine, Gainesville, FL

  • Section of Urology, Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, IL

  • Transplantation Biology Department, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

  • Penn State Hershey Cancer Institute, Department of Medicine (Hematology/Oncology), Penn State College of Medicine, Hershey, PA.

  • ALLIANCE, Boston, MA

  • Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA

  • Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX

  • Alliance for Clinical Trials in Oncology Statistics and Data Center, Rochester, MN

  • Hematology/Oncology and Comprehensive Cancer Center, University of Chicago, Chicago, IL

  • Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA

  • Lymphoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY

  • Alliance for Clinical Trials in Oncology Statistics and Data Center, Duke University Medical Center, Durham, NC

  • Dana-Farber Cancer Institute, Boston, MA

  • Maine Childrens Cancer Program, Scarborough, ME

  • Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Gastroenterology (GU)

Disease

  • Acute lymphoblastic leukemia

  • Hyperbilirubinemia

  • Hyperglycemia

  • Pancreatitis

  • Neutropenia

  • Peripheral neuropathy

  • Venous thrombosis

  • Mucositis

Biomarkers

  • Breakpoint Cluster Region

Drug/Treatment

  • PEG-asparaginase

  • Methotrexate

  • Asparaginase

  • Prednisone

Outcome

  • N/A

Study Design

  • single arm

  • randomized

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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