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3768 : Pcft Is Silenced By DNA Methylation In Pediatric Acute Lymphoblastic Leukemia Resulting In Decreased Methotrexate Uptake

Researchers

Presenter

  • Calvin K. Lee

Principal Investigators

  • Weijie Poh

  • Megan Healey

  • Eric S Schafer

  • Patrick Brown

  • James G. Herman

Medical Centers

  • Pediatric Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD

  • Cancer Biology Program, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

  • The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD

  • Department of Pediatrics, All Childrens Hospital Johns Hopkins Medicine, St. Petersburg, FL

  • Pathobiology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD

  • Baylor College of Medicine, Houston, TX

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • B-cell acute lymphoblastic leukemia

  • T-cell acute lymphoblastic leukemia

  • Solid malignancies

Biomarkers

  • Breakpoint Cluster Region

  • Methylenetetrahydrofolate reductase

  • DNA methylation

Drug/Treatment

  • Decitabine

  • Methotrexate

  • Fluorescein sodium

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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