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3759 : Leukemia Driven By a NUP98-Phd Domain Fusion Is Highly Sensitive To Disruption Of H3K4me3-Phd Domain Binding By a Small Molecule Inhibitor

Researchers

Presenter

  • Sheryl M Gough

Principal Investigators

  • Fan Lee

  • Robert L Walker

  • Yi Ning

  • Paul S Meltzer

  • Peter D Aplan

  • Fan Yang

  • Yuelin Zhu

  • Marbin Pineda

  • Masahiro Onozawa

  • Yang Jo Chung

  • Sven Bilke

  • Elise K Wagner

  • John M Denu

Medical Centers

  • Genetics Branch, NIH/NCI/CCR, Bethesda, MD

  • Johns Hopkins University, Baltimore, MD

  • Univeristy of Wisconsin, Madison, WI

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Hematological malignancies

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • Histone-lysine N-methyltransferase 2A

  • Homeobox A9

Drug/Treatment

  • Disulfiram

  • Alconil

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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