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234 : Genomic- and Transcriptomic Profiling Of Acute Lymphoblastic Leukemia With Dicentric Chromosomes

Researchers

Presenter

  • Linda Holmfeldt

Principal Investigators

  • Paolo Vignali

  • Debbie Payne-Turner

  • Stephen P. Hunger

  • Mignon L. Loh

  • Charles G. Mullighan

  • Jing Ma

  • Guangchun Song

  • Pankaj Gupta

  • Michael Rusch

  • Jinghui Zhang

  • Nyla A. Heerema

  • Susana C. Raimondi

  • Andrew J. Carroll

Medical Centers

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO

  • Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL

  • Computational Biology, St Jude Children's Research Hospital, Memphis, TN

  • Department of Pathology, The Ohio State University, Columbus, OH

  • Dept. of Pathology, MS #, St. Jude Children's Rsch. Hosp., Memphis, TN

  • St. Jude Children's Research Hospital, Memphis, TN

  • Computational Biology, St Jude Children's Research Hospital, Memphis, TN

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • St. Jude Children's Research Hospital, Memphis, TN

  • Neonatology, Benioff Childrens Hospital, University of California San Francisco, San Francisco, CA

  • St. Jude Children's Research Hospital, Memphis, TN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • MYCN proto-oncogene, bHLH transcription factor

  • Neurogenic locus notch homolog protein 1

  • Breakpoint Cluster Region

  • Phosphatase and tensin homolog

  • Protein Tyrosine Phosphatase, Non-Receptor Type 11

  • Hepatocyte growth factor receptor

  • Cyclin Dependent Kinase Inhibitor 2A

  • Cyclin Dependent Kinase Inhibitor 2B

  • GTPase Nras

  • Janus kinase 3

  • KRAS proto-oncogene, GTPase

  • Signal transducer and activator of transcription 3

  • Tumor protein p53

  • Neurofibromatosis type 1

Drug/Treatment

  • L-Tyrosine

  • TP53

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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