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229 : Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia

Researchers

Presenter

  • Zhengshan Chen

Principal Investigators

  • Seyedmehdi Shojaee

  • Huimin Geng

  • Jae U. Jung

  • Hassan Jumaa

  • John E. Coligan

  • Silvia Bolland

  • Tak W. Mak

  • Markus Muschen

  • Jaewoong Lee

  • Maike Buchner

  • Lars Klemm

  • Clifford A. Lowell

  • Elisabeth M. Paietta

  • Cheryl L. Willman

  • William L. Carroll

  • Ari M. Melnick

Medical Centers

  • Medical Biophysics and Immunology, The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada

  • Cancer Center/Pathology, University of New Mexico, Albuquerque, NM

  • Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY

  • Montefiore Medical Center, Bronx, NY

  • Icahn School of Medicine, New York, NY

  • Receptor Cell Biology Section, National Institutes of Health, Rockville, MD

  • Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA

  • Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA

  • Molecular Immunology, Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

  • NIAID/NIH, Rockville, MD.

Locations

  • United States

  • Canada

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Solid malignancies

Biomarkers

  • Breakpoint Cluster Region

  • p53

  • Phospho-ERK

  • Cluster of Differentiation 31

  • Cluster of differentiation 79A

  • Proto-oncogene tyrosine-protein kinase ROS

  • GTPase Nras

  • Src homology region 2 domain-containing phosphatase-1

Drug/Treatment

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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