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195 : Thrombosis Protection In Klkb1-/- (Prekallikrein KO) Mice Is Mediated By Increased Renal Mas Receptor, Plasma Prostacyclin, and Aortic Sirt1

Researchers

Presenter

  • Chao Fang

Principal Investigators

  • Evi Stavrou

  • Yunmei Wang

  • Nadja Grobe

  • Daniel I. Simon

  • Alvin H. Schmaier

Medical Centers

  • Division of Hematology-Oncology, Case Western Reserve University, Cleveland, OH

  • Division of Cardiovascular Medicine, Case Western Reserve University, Cleveland, OH

  • University Hospitals Cleveland Medical Center / Case Western Reserve University School of Medicine, Cleveland, OH

  • Department of Pharmacology and Toxicology, Wright State University, Dayton, OH

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

  • Blood/haematological Diseases

  • Pulmonary/Respiratory Diseases

Disease

  • Venous thrombosis

  • Pyruvate kinase (PK) deficiency

Biomarkers

  • Fragment 1+2

  • Activated partial thromboplastin time

Drug/Treatment

  • Thrombomodulin alfa

  • Prostacyclin

  • Epinephrine

  • Adrenaclick

  • Rose bengal sodium

  • Angiotensin II

  • Evithrom

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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