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3286 : Results Of a Phase I Study Of Clofarabine and 2 Gy Total Body Irradiation (TBI) As a Non-Myeloablative Preparative Regimen For Hematopoietic Stem Cell Transplantation (HSCT) In High Risk Children With Hematologic Malignancies: A Multi-Center TACL Study

Researchers

Presenter

  • Sandeep Soni

Principal Investigators

  • Hisham Abdel-Azim

  • Elena Eckroth

  • Jeanette van der Geissen

  • Meghann Pine McManus

  • Eneida R. Nemecek

  • Richard Sposto

  • Blythe Thompson

  • Ann E Woolfrey

  • Haydar A Frangoul

Medical Centers

  • Therapeutic Advances for Childhood Leukemia TACL, Children's Hospital of Los Angeles, Los Angeles, CA

  • Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA

  • Department of Hematology Oncology and BMT, Nationwide Children's Hospital, Columbus, OH

  • Pediatrics, University of Utah/Primary Children's Medical Center, Salt Lake City, UT

  • Pediatric Hematology/Oncology & Bone Marrow Transplantation, Oregon Health & Science University, Portland, OR

  • Dept. of Pediatrics, Div. of Hematology, Oncology and Blood& Bone Marrow Transplantation, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA

  • Vanderbilt University, Nashville, TN

  • Division of Hematology., Oncology and BMT, Seattle Children's Hospital, Seattle, WA

  • Transplantation Biology Department, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • Hematological malignancies

  • Down syndrome

  • Graft-versus-host disease

Biomarkers

  • Alanine transaminase

  • Aspartate aminotransferase

  • Breakpoint Cluster Region

  • Circulating tumor cells

  • Cluster of Differentiation 2AP

  • Cluster of Differentiation 34

  • Creatinine

  • Interleukin 1 alpha

Drug/Treatment

  • Mycophenolate mofetil

  • CKD-4101

  • Cyclosporine eent

  • Clofarabine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • I

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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