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2679 : Safety, Pharmacokinetics, and Efficacy Of BP-100-1.01 (Liposomal Grb-2 Antisense Oligonucleotide) In Patients With Refractory Or Relapsed Acute Myeloid Leukemia (AML), Philadelphia Chromosome Positive Chronic Myelogenous Leukemia (CML), Acute Lymphoblastic Leukemia (ALL), and Myelodysplastic Syndrome (MDS)

Researchers

Presenter

  • Maro Ohanian

Principal Investigators

  • Hagop M. Kantarjian

  • Farhad Ravandi

  • Ana Tari

  • Srdan Verstovsek

  • William G. Wierda

  • Jorge Cortes

  • Gautam Borthakur

  • Guillermo Garcia-Manero

  • Michael Andreeff

  • Elias Jabbour

  • Marina Konopleva

  • Susan -Brien

  • Alfonso Quintas-Cardama

  • Bradley G. Somer

Medical Centers

  • The University of Texas MD Anderson Cancer Center, Department of Neurosurgery, Houston, TX

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, HOUSTON, TX

  • West Clinic, Memphis, TN

  • Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • Department of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX

Locations

  • United States

Companies

  • Bio-Path Holdings, I

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Chronic Myelogenous Leukemia

  • Alpha-thalassemia myelodysplasia syndrome

  • Hematological malignancies

  • Acute myelocytic leukemia

  • Leptomeningeal Metastasis

  • Hand foot syndrome

  • Mucositis

  • Solid malignancies

Biomarkers

  • Breakpoint Cluster Region

  • Extracellular signal-regulated kinase

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

Drug/Treatment

  • Liposomal Grb-2

  • Hydroxyurea

  • Hydroxycarbamide

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • pharmacokinetics

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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