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2510 : The Beta-Subunit Of Heterotrimeric G Proteins Harbors Gain-Of-Function Mutations In Multiple Hematologic Malignancies

Researchers

Presenter

  • Akinori Yoda

Principal Investigators

  • Guillaume Adelmant

  • Nobuaki Shindoh

  • Jeffrey W. Tyner

  • Jason R. Gotlib

  • Michael W. Deininger

  • Shannon Turley

  • Jarrod A Marto

  • Andrew A. Lane

  • David M. Weinstock

  • Bjoern Chapuy

  • Yuka Yoda

  • Oliver Weigert

  • Nadja Kopp

  • Shuo-Chieh Wu

  • Sunhee S. Kim

  • Huiyun Liu

  • Trevor Tivey

Medical Centers

  • Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA

  • Dana-Farber Cancer Institute, Boston, MA

  • Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

  • Department of Cell & Developmental Biology, Oregon Health & Science University, Portland, OR

  • Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

  • Klinikum Der Universitaet Muenchen-Campus Grosshadern, Munich, Germany

  • Stanford School of Medicine, Stanford, CA

  • Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT

Locations

  • United States

  • Germany

Companies

  • Astellas Pharma Inc.

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Blastic plasmacytoid dendritic cell neoplasm

  • B-cell acute lymphoblastic leukemia

  • Acute lymphoblastic leukemia

  • Chronic Lymphocytic Leukemia

  • Hematological malignancies

  • Myeloid neoplasms

  • B cell lymphomas

  • Pituitary adenomas

  • Uveal melanoma

  • T-cell acute lymphoblastic leukemia

  • Lymphomas

  • Melanoma

  • Solid malignancies

Biomarkers

  • Mitogen-activated protein kinase

  • Breakpoint Cluster Region

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Cluster of Differentiation 11c

  • Cluster of Differentiation 19

  • Cluster of Differentiation 2

  • Cluster of Differentiation 26

  • Cluster of Differentiation 2AP

  • Cluster of differentiation 45

  • Cluster of differentiation 8A

  • Cyclin Dependent Kinase Inhibitor 2A

  • Extracellular signal-regulated kinase

  • Fms related tyrosine kinase 3

  • G Protein Subunit Alpha 11

  • G protein subunit alpha q

  • PI3K/AKT

Drug/Treatment

  • Adrucil injection

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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