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1387 : Reversing Vascular Dysfunction In Rheumatoid Arthritis: Peroxisome Proliferator-Activated Receptor Gamma Agonist Therapy Improves Augmentation Index But Not Endothelial Function

Researchers

Presenter

  • Michelle J. Ormseth

Principal Investigators

  • Aihua Bian

  • Annette M. Oeser

  • Andrew Cunningham

  • Ayumi Shintani

  • S. Bobo Tanner

  • C. Michael Stein

Medical Centers

  • Medicine, Vanderbilt Medical Center, Nashville, TN

  • Vanderbilt University Medical Center, Nashville, TN

  • Div of Rheumatology & Allergy, Vanderbilt Medical Center, Nashville, TN

  • School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • Rheumatoid arthritis

Biomarkers

  • C reactive protein

  • Peroxisome proliferator-activated receptor gamma

  • High sensitivity C-reactive protein

Drug/Treatment

  • Pioglitazone

  • Actoplus Met XR extended-release tablet

Outcome

  • N/A

Study Design

  • randomized

Phase

  • N/A

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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