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4437 : The relevance of aberrant FPGS splicing for ex vivo MTX resistance and clinical outcome in childhood acute lymphoblastic leukemia

Researchers

Presenter

  • Anna Wojtuszkiewicz

Principal Investigators

  • Yehuda G. Assaraf

  • Mirthe Hoekstra

  • Gerrit Jansen

  • Godefridus J. Peters

  • Edwin Sonneveld

  • Gertjan L. Kaspers

  • Jacqueline Cloos

Medical Centers

  • Dutch Childhood Oncology Group, The Hague, Netherlands.

  • Academic Medical Center, Amsterdam, Netherlands

  • Technion israel institute of technology, Haifa, Israel.

Locations

  • Israel

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

Disease

  • Acute lymphoblastic leukemia

  • Solid malignancies

  • Dihydrofolate reductase (DHFR) deficiency

Biomarkers

  • Breakpoint Cluster Region

  • Dihydrofolate reductase

  • White Blood Cell

Drug/Treatment

  • Glucocorticoid

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • Methotrexate

  • Prednisone

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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