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1334 : Biomarkers Accurately Predict Cytokine Release Syndrome (CRS) after Chimeric Antigen Receptor (CAR) T Cell Therapy for Acute Lymphoblastic Leukemia (ALL)

Researchers

Presenter

  • David T Teachey

Principal Investigators

  • Simon F. Lacey

  • Pamela A Shaw

  • M.B.A

  • Edward Pequignot

  • Susan R. Rheingold

  • J Joseph Melenhorst

  • Noelle V. Frey

  • Shannon L Maude

  • David M. Barrett

  • Richard Aplenc

  • Fang Chen

  • Julie Fitzgerald

  • Vanessa Gonzalez

Medical Centers

  • Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA

  • Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA

  • Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA

  • University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

  • Translational and Correlational Studies Laboratory, University of Pennsylvania, Philadelphia, PA

  • Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA

  • Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

  • Fort Belvoir Community Hospital, Fort Belvoir, VA

  • Department of Medicine, University of Pennsylvania, Philadelphia, PA

  • Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA

  • Center for Childhood Cancer Research, Childrens Hospital of Philadelphia, Philadelphia, PA

  • Childrens Hospital of Philadelphia, Philadelphia, PA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Musculoskeletal

Disease

  • Macrophage activation syndrome

  • Acute lymphoblastic leukemia

  • Cytokine release syndrome

  • Hematological malignancies

  • Craniosynostosis 1

  • Craniosynostosis 4

Biomarkers

  • C-C Motif Chemokine Ligand 2

  • Aspartate aminotransferase

  • Breakpoint Cluster Region

  • C reactive protein

  • Cluster of Differentiation 2AP

  • Coxsackie Virus And Adenovirus Receptor

  • C-X-C motif chemokine ligand 8

  • Cytokine

  • Granulocyte-macrophage-colony stimulating factor

  • Interleukin 13

  • Interleukin 6

  • Lactate dehydrogenase

  • Twist-related protein 1

Drug/Treatment

  • Tocilizumab

  • CTL019

  • GM-CSF

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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