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1331 : A Photosensitizer Verteporfin Has Light-Independent Anti-Leukemic Activity for Ph-Positive Acute Lymphoblastic Leukemia and Synergistically Works with Dasatinib in Vivo

Researchers

Presenter

  • Takanobu Morishita

Principal Investigators

  • Fumihiko Hayakawa

  • Keiki Sugimoto

  • Daiki Hirano

  • Yuki Kojima

  • Naoto Imoto

  • Yuichiro Inagaki

  • Tomoki Naoe

  • Hitoshi Kiyoi

Medical Centers

  • Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan

  • National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan

  • Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo,

  • Department of Pathologic Oncology, Mie University Graduate School of Medicine, Mie, Japan

Locations

  • Japan

Companies

  • Otsuka Pharmaceutica

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Age-Related Macular Degeneration

  • Philadelphia chromosome–positive (Ph+) ALL

  • Solid malignancies

Biomarkers

  • Abelson murine leukemia viral oncogene homolog

  • Proto-oncogene tyrosine-protein kinase ROS

  • Histone-lysine N-methyltransferase 2A

Drug/Treatment

  • glutathione

  • verteporfin

  • dasatinib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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