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1283 : Activation of Simultaneous Apoptosis and Necroptosis to Eradicate Drug Resistant Leukemia

Researchers

Presenter

  • Scott McComb

Principal Investigators

  • Julia Aguade-Gorgorio

  • Blerim Marovca

  • Lena Harder

  • Gunnar Cario

  • Cornelia Eckert

  • Martin Schrappe

  • Martin Stanulla

  • Arend von Stackelberg

  • Jean-Pierre Bourquin

  • Beat Bornhauser

Medical Centers

  • Paediatric Oncology and Hematology Charite, University Hospital Berlin, Berlin, Germany

  • Department of Pediatric Oncology/Hematology, Charite Medical University Berlin, Berlin, Germany.

  • Dept. of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

  • Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany

  • Department of Neurology, University Hospital Zurich, Zurich, Switzerland

Locations

  • Germany

  • Switzerland

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Second mitochondria-derived activator of caspase

  • TNF Receptor Superfamily Member 1A

  • TNF Receptor Superfamily Member 1B

  • Tumor necrosis factor

Drug/Treatment

  • birinapant

  • LCL 161

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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