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1033 : Platelet CD36 Induces ERK5 Activation through a Redox-Regulated Signaling Pathway to Promote a Prothrombotic Phenotype

Researchers

Presenter

  • Moua Yang

Principal Investigators

  • Jeannette M. Vasquez-Vivar

  • Yiliang Chen

  • Scott J. Cameron

  • Craig N. Morrell

  • Roy L. Silverstein

Medical Centers

  • Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI.

  • Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI.

  • Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY

  • Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI

  • Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

Disease

  • Coronary Artery Disease

  • Myocardial infarction

  • Atherothrombosis

  • Venous thrombosis

  • Stroke

Biomarkers

  • Mitogen-activated protein kinase

  • Oxidized LDL

  • Proto-oncogene tyrosine-protein kinase ROS

Drug/Treatment

  • Hydrogen peroxide

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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