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1293 : Small Molecule Inhibition of LARG/RhoA Signaling Blocks Migration of ETV6-RUNX1 Positive B-Cell Precursor Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Roel Polak

Principal Investigators

  • Marc B Bierings

  • Rob Pieters

  • Miranda Buitenhuis

  • Monique L. den Boer

Medical Centers

  • Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands

  • Department of Hematology and Immunology, Wilhelmina Childrens Hospital, Utrecht, Netherlands

  • Princess Maxima Center for Pediatric Oncology, Netherlands

Locations

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Mitogen-activated protein kinase

  • AKT Serine

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • CREB-binding protein

  • C-X-C motif chemokine receptor 4

  • ETV6-RUNX1

  • Extracellular signal-regulated kinase

  • Janus kinase

  • Mesenchymal stem cells

  • Stromal cell-derived factor 1

  • MAPK/ERK

Drug/Treatment

  • Asparaginase

  • Prednisolone

  • Plerixafor

  • AMD-3100

  • CXCL12

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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