// App-Quantinova.ai

1435 : Loss of Pigh Expression Frequently Results in a GPI-Negative Subclone Lacking CD52 Membrane Expression, Conferring Alemtuzumab Resistance to B Cell Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Floris C. Loeff

Principal Investigators

  • Kevin Rijs

  • Willem H. Zoutman

  • Esther H.M. Egmond

  • Maarten H. Vermeer

  • J.H. Frederik Falkenburg

  • Constantijn J.M. Halkes

  • Inge Jedema

Medical Centers

  • Department of Urology, Leiden Unviersity Medical Center, Leiden, Netherlands

  • Department of Urology, Leiden Unviersity Medical Center, Leiden, Netherlands

Locations

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Chronic Lymphocytic Leukemia

  • Mantle cell lymphoma

  • Hairy cell leukemia

  • Lymphomas

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • Glycosylphosphatidylinositol

Drug/Treatment

  • Vidaza

  • Alemtuzumab

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

Copyright © 2026. QuantiNova All rights reserved