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1434 : CD25 (IL2RA) Orchestrates Negative Feedback Control and Stabilizes Oncogenic Signaling Strength in Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Jae-Woong Lee

Principal Investigators

  • Zhengshan Chen

  • Huimin Geng

  • Gang Xiao

  • Eugene Park

  • Samir Parekh

  • Steven M. Kornblau

  • Ari Melnick

  • Abul Abbas

  • Elisabeth Paietta

  • Markus Muschen

Medical Centers

  • Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

  • Weill Cornell Medical College, New York, NY

  • Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA

  • MD Anderson Cancer Center, University of Texas, Houston, TX

  • Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA

  • Albert Einstein College of Medicine, Great Neck, NY

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Phosphatase and tensin homolog

  • Cluster of Differentiation 25

  • Protein Phosphatase 2 Phosphatase Activator

  • Extracellular signal-regulated kinase

  • Interleukin-2

  • Src homology region 2 domain-containing phosphatase-1

  • Regulatory T cells

Drug/Treatment

  • Vincristine

  • Interleukin

  • Ibrutinib

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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