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80 : A Multicenter Phase II Study Using a Dose Intensified Pegylated-Asparaginase Pediatric Regimen in Adults with Untreated Acute Lymphoblastic Leukemia: A DFCI ALL Consortium Trial

Researchers

Presenter

  • Daniel J. DeAngelo

Principal Investigators

  • Kristen Stevenson

  • Donna S Neuberg

  • Stephen Couban

  • William Blum

  • John Storring

  • Lewis B. Silverman

  • Karen K. Ballen

  • Julie D. Asch

  • Yasser Abou Mourad

  • Kristjan Paulson

  • Matthew D. Seftel

  • David Avigan

  • Julie Bergeron

Medical Centers

  • Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

  • Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada

  • Medical Oncology, Montreal General Hospital, Montreal, QC, Canada

  • Intermountain Blood and Marrow Transplant/Acute Leukemia Program, Salt Lake City, UT

  • Massachusetts General Hospital, Boston, MA

  • Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

  • Cancer Care Manitoba, Winnipeg, MB, Canada

  • Beth Israel Deaconess Medical Center, Boston, MA

  • Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, United States

  • The James Comprehensive Cancer Center, Ohio State University, Columbus, OH

  • Department of Medical Oncology/Hematology, CancerCare Manitoba, Winnipeg, MB, Canada

  • Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Childrens Hospital, Boston, MA

  • Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

  • Vancouver General Hospital, BC Cancer Center, Vancouver, BC, Canada

Locations

  • United States

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Ph chromosome

Drug/Treatment

  • 6-mercaptopurine

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • Methotrexate

  • Asparaginase

  • Vincristine

  • Doxorubicin

  • Cytarabine liposomal

  • Prednisone

  • Etoposide

  • Etoposide phosphate

  • Imatinib

  • IkT001

Outcome

  • N/A

Study Design

  • N/A

Phase

  • II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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