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100 : CD4 CAR T Cells Mediate CD8-like Cytotoxic Anti-Leukemic Effects Resulting in Leukemic Clearance and Are Less Susceptible to Attenuation By Endogenous TCR Activation Than CD8 CAR T Cells

Researchers

Presenter

  • Yinmeng Yang

Principal Investigators

  • Tasha Lin

  • Elad Jacoby

  • Haiying Qin

  • Elizabeth Grier Gardner

  • Christopher Daniel Chien

  • Daniel W. Lee III

  • Terry J. Fry

Medical Centers

  • Tumor Biology Department, Georgetown University, Washington, DC

  • Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Cluster of Differentiation 107 Antigen-Like Family Member A

  • Cluster of Differentiation 2AP

  • Cluster of Differentiation 4

  • Programmed cell death protein 1

  • Coxsackie Virus And Adenovirus Receptor

  • T cell activity

  • T-cell receptor

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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