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922 : L-Asparaginase Causes Metabolic Reprogramming in ALL Cells

Researchers

Presenter

  • Ivana Hermanova

Principal Investigators

  • Karel Valis

  • Hana Nuskova

  • Petr Novak

  • Tomas Mracek

  • Arkaitz Carracedo

  • Meritxell Alberich-Jorda

  • Amaia Arruabarrena Aristorena

  • Sonia Fernandez-Ruiz

  • Simona Bartova

  • Alena Pecinova

  • Daniel Kavan

  • Karel Fiser

  • Marek Kuzma

Medical Centers

  • CIC bioGUNE Technology Park of Bizkaia, Derio, Spain

  • Department of Bioenergetics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

  • Department of Biochemistry and Molecular biology, University of the Basque Country, Leioa, Spain

  • Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic

  • Ikerbasque, Basque Foundation for Science, Bilbao, Spain

  • Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

  • Childhood Leukaemia Investigation Prague, Department of Pediatric Hematology/Oncology, 2nd Faculty of Medicine, Charles University Prague, Prague, Czech Republic

Locations

  • Spain

  • Czech Republic

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Mismatch repair deficiency

  • Solid malignancies

Biomarkers

  • Breakpoint Cluster Region

  • cMYC

Drug/Treatment

  • Asparaginase

  • Glutamine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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