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972 : Targeted Inhibition of the MLL Transcriptional Complex By Proteosome Inhibitors Elicits a High Response Rate in Relapsed/Refractory MLL Rearranged Leukemia

Researchers

Presenter

  • Cary Koss

Principal Investigators

  • Stephanie Nance

  • Michele Connelly

  • James R Downing

  • R. Kiplin Guy

  • Tanja A Gruber

  • Jing Ma

  • Anang Shelat

  • Anitria Cotton

  • Qi An

  • Cheng Cheng

  • Monika L. Metzger

  • Sima Jeha

  • Jeffrey E Rubnitz

Medical Centers

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Chemical Biology and Therapeutics, St. Jude Childrens Research Hospital, Memphis, TN

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Cluster of Differentiation 25

  • H2B monoubiquitination

  • Histone-lysine N-methyltransferase 2A

Drug/Treatment

  • Mitoxantrone

  • Bortezomib

  • Vorinostat

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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