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10039 : Anti-tumor efficacy in SIOPEL 6: A multi-centre open label randomised phase III trial of the efficacy of sodium thiosulphate (STS) in reducing ototoxicity in patients receiving cisplatin (Cis) monotherapy for standard risk hepatoblastoma (SR-HB).

Researchers

Presenter

  • Penelope Rachel Brock

Principal Investigators

  • Margaret Childs

  • Eiso Hiyama

  • Benedicte Brichard

  • Jane Skeen

  • Maria Elena Mateos

  • Monique Fabre

  • Arun Atreiya Rangaswami

  • Michael Capra

  • Piotr Czauderna

  • Derek Roebuck

  • Michael James Sullivan

  • Veronique Laithier

  • Milind Ronghe

  • Liane Lockwood

  • Patrizia dall'Igna

  • Bruce Morland

  • Kaukab Rajput

  • Edward A. Neuwelt

Medical Centers

  • Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom

  • Royal Children's Hospital, Melbourne, Victoria, Australia

  • Medical University of Gdansk, Gdansk, Poland

  • Paediatric Haematology Oncology Division, University of Padova, Padova, Italy

  • Great Ormond Street Hospital, London, United Kingdom

  • Hiroshima University, Hiroshima-Shi, Japan

  • Institut de Cancerologie Gustave Roussy, Villejuif, France

  • University Hospital Reina Sofia, Cordoba, Spain

  • Royal Hospital for Sick Children, Glasgow, United Kingdom

  • Cliniques Universitaires Saint-Luc, UCL, Brussels, MN, Belgium

  • Centre Hospitalier Universitaire Besancon, Besancon, FranceRoyal Childrens Hospital, Brisbane, AustraliaOur Ladys Childrens Hospital, Crumlin, Dublin, Ireland

  • Stanford Univ, Palo Alto, CA

  • Oregon Health and Science University, Portland, OR

  • Starship Children's Hospital, Auckland, New Zealand

  • Nottingham Clinical Trials Unit, Nottingham, United Kingdom

  • Birmingham Children's Hospital, Birmingham, United Kingdom

  • International Breast Cancer Study Group (IBCSG), Bern, Switzerland

Locations

  • Ireland

  • Japan

  • Italy

  • Poland

  • Spain

  • United Kingdom

  • Switzerland

  • Australia

  • United States

  • France

  • Belgium

  • New Zealand

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Hepatoblastoma

Biomarkers

  • Alpha-fetoprotein

Drug/Treatment

  • sodium thiosulfate

  • Doxorubicin

  • Cisplatin

Outcome

  • N/A

Study Design

  • open label

  • randomized

Phase

  • III

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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