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11101 : Sensitivity and specificity of an oral uracil-loading test dose for screening for DPD deficiency.

Researchers

Presenter

  • M C van Staveren

Principal Investigators

  • Andre B. P. van Kuilenburg

  • Hans Gelderblom

  • Jan Gerard Maring

  • Henk-jan Guchelaar

  • Robert De Jong

  • Cornelis J. A. Punt

Medical Centers

  • Scheper Hospital Emmen, Emmen, Netherlands

  • Martini Hospital, Groningen, NetherlandsDepartment of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Pharmacy, Diaconessen Hospital Meppel and Bethesda Hospital Hoogeveen, Meppel, Netherlands

  • Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

  • Laboratory of Genetic and Metabolic Diseases, Academic Medical Center Amsterdam, Amsterdam, Netherlands

  • Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, Netherlands

Locations

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Dihydropyrimidine dehydrogenase deficiency

  • Solid malignancies

Biomarkers

  • Peripheral blood mononuclear cell

  • Circulating tumor cells

  • Deoxypyridinoline

Drug/Treatment

  • Adrucil injection

Outcome

  • Positive

Study Design

  • pharmacokinetics

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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