// App-Quantinova.ai

TPS669 : Phase Ib trial of trastuzumab emtansine (TE) in combination with lapatinib (L) plus nab-paclitaxel in metastatic HER2-neu overexpressed breast cancer patients: STELA trial.

Researchers

Presenter

  • Tejal Amar Patel

Principal Investigators

  • Jaime Alberto Mejia

  • Angel Augusto Rodriguez

  • Jenny Chee Ning Chang

Medical Centers

  • The Methodist Hospital Research Institute, Houston, TX

  • Houston Methodist Research Institue, Houston, TXHouston Methodist Cancer Center, Houston, TX

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Peripheral neuropathy

  • Breast cancer

  • Solid malignancies

Biomarkers

  • Phosphatase and tensin homolog

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Human epidermal growth factor receptor 2

Drug/Treatment

  • Trastuzumab emtansine

  • Paclitaxel

  • Lapatinib

  • Protein-bound paclitaxel

Outcome

  • Unknown

Study Design

  • pharmacokinetics

  • pharmacodynamics

Phase

  • I

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

Copyright © 2026. QuantiNova All rights reserved