// App-Quantinova.ai

5175 : Mutational and copy number profiling of cancer-related genes in 26 human tumor xenografts and their correlations with antitumor drug sensitivities

Researchers

Presenter

  • Takashi Kobunai

Principal Investigators

  • Kenta Tsunekuni

  • Kazuaki Matsuoka

  • Hiroshi Tsukihara

  • Teiji Takechi

Medical Centers

  • Taiho Pharmaceutical Co., LTD., Tokyo, Japan

  • Graduate School of Medicine, Osaka City University, Osaka, Japan

Locations

  • Japan

Companies

  • Taiho Pharmaceutical

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Solid malignancies

Biomarkers

  • Adenomatous Polyposis Coli

  • Neurogenic locus notch homolog protein 1

  • beta-catenin

  • B-Raf proto-oncogene, serine/threonine kinase

  • Cadherin 1

  • Phosphatase and tensin homolog

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Ret Proto-Oncogene

  • Epidermal growth factor receptor

  • G protein subunit alpha q

  • HRas Proto-Oncogene, GTPase

  • Isocitrate dehydrogenase 1

  • KIT Proto-Oncogene, Receptor Tyrosine Kinase

  • KRAS proto-oncogene, GTPase

  • Liver kinase B1

  • Tumor protein p53

Drug/Treatment

  • Capecitabine

  • Paclitaxel

  • Irinotecan

  • Tegafur/gimeracil/oteracil

  • TP53

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

Copyright © 2026. QuantiNova All rights reserved