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4669 : Targeting hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells

Researchers

Presenter

  • Fernanda Faiao-Flores

Principal Investigators

  • Debora Kristina Magalhaes Alves-Fernandes

  • Paula Comune Pennacchi

  • Silvana Sandri

  • Anna Luiza Silva Almeida Vicente

  • Cristovam Scapulatempo-Neto

  • Vinicius de Lima Vazquez

  • Rui Manuel Reis

  • Keiran S. Smalley

  • Silvya Stuchi Maria-Engler

Medical Centers

  • School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil

  • Barretos Cancer Hospital, Barretos, Brazil

  • H. Lee Moffitt Cancer Center & Research Institute, Riverview, FL

Locations

  • Brazil

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Skin carcinoma

  • Melanoma

  • Solid malignancies

  • Gliomas

Biomarkers

  • B-Raf proto-oncogene, serine/threonine kinase

  • GLI Family Zinc Finger 1

Drug/Treatment

  • Vemurafenib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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