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4657 : Selective inhibitors epigenetically modify and eradicate tumor-initiating stem-like cells through downregulating microRNA 22-mediated TET induction and apoptosis

Researchers

Presenter

  • Chia-Lin Chen

Principal Investigators

  • Suresh Swaminathan

  • Ameya Kirtane

  • Jayanth Panyam

  • Keigo Machida

Medical Centers

  • University of Southern California, Los Angeles, CA

  • University of Minnesota, Minneapolis, MN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Solid malignancies

Biomarkers

  • NANOG

  • Aryl hydrocarbon receptor nuclear translocator-like protein 1

  • BCL2 like 11

  • Phosphatase and tensin homolog

  • Prominin 1

  • Tet methylcytosine dioxygenase 2

  • Toll like receptor 4

Drug/Treatment

  • Vorinostat

  • Tretinoin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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