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4019 : Inhibiting DNA methylation causes an interferon response in cancer cells via endogenous retroviruses and recruits immune cells to the tumor microenvironment to sensitize to immune therapy

Researchers

Presenter

  • Katherine B. Chiappinelli

Principal Investigators

  • Meredith L. Stone

  • Michael J. Topper

  • Lauren Murphy

  • Pamela L. Strissel

  • Reiner Strick

  • Cynthia A. Zahnow

  • Stephen B. Baylin

Medical Centers

  • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine,, Baltimore, MD

  • Laboratory for Molecular Medicine, University-Clinic Erlangen, Erlangen, Germany.

Locations

  • United States

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Ovarian cancer

  • Solid malignancies

  • Melanoma

Biomarkers

  • Cluster of Differentiation 2AP

  • Programmed death-ligand 1

  • Cluster of differentiation 8A

  • Interferon

  • DNA methylation

Drug/Treatment

  • 5-Azacytidine

  • Interferon

  • Anti-CTLA4

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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