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4003 : Metformin reduces intratumoral CD8+PD-1+ and Treg lymphocytes in orthotopic models of breast cancer and lymphoma, and has paradoxic effects on anti-PD-L1 treatment

Researchers

Presenter

  • Stefania Orecchioni

Principal Investigators

  • Giovanna Talarico

  • Patrizia Mancuso

  • Valentina Labanca

  • Francesca Reggiani

  • Francesco Bertolini

Medical Centers

  • European Institute of Oncology, Milan, Italy

Locations

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Triple-negative breast cancer

  • B cell lymphomas

  • Type 2 diabetes mellitus

  • Breast cancer

  • Solid malignancies

  • Lymphomas

  • Diabetes

Biomarkers

  • AMP-activated protein kinase

  • Cluster of Differentiation 4

  • Cluster of differentiation 8A

  • Granulocyte-macrophage-colony stimulating factor

  • tumor-infiltrating lymphocytes

  • Regulatory T cells

Drug/Treatment

  • Metformin Hydrochloride

  • GM-CSF

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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