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3849 : The antidiabetic drug metformin increases pro-apoptotic effect of TRAIL therapy by reducing X-linked inhibitor of apoptosis protein (XIAP) levels in triple-negative breast cancer cells

Researchers

Presenter

  • Elena Strekalova

Principal Investigators

  • Dmitry Malin

  • Vincent Cryns

Medical Centers

  • Univeristy of Wisconsin, Madison, WI

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Triple-negative breast cancer

  • Diabetes

  • Solid malignancies

Biomarkers

  • Nucleoside diphosphate kinase A

  • X-linked inhibitor of apoptosis

Drug/Treatment

  • lexatumumab

  • Metformin Hydrochloride

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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